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Are There any Side Effects of the Headache Killer Fioricet?

Are there any negative side effects of the pain killer Fioricet?

the doctor prescribed Fioricet to me with regard to my migraines. My Rx says that I can take two tablets – 4 times a day. Are there any known long term side effects from using this drug? I take them pretty regularly.

There are maybe a lot of answers for this question. But I think the best answer is:

Answer by Comrade Demitri Dingleberry
Plague and genital rodents.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Lightheadedness
  2. shortness of breath

Incidence not known

  1. Abdominal or stomach pain
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, or loosening of the skin
  5. blood in the urine or stools
  6. blurred vision
  7. change in the frequency of urination or amount of urine
  8. chills
  9. cough
  10. diarrhea
  11. difficulty with breathing
  12. difficulty with swallowing
  13. dizziness
  14. drowsiness
  15. dry mouth
  16. fainting
  17. fast, pounding, or irregular heartbeat or pulse
  18. flushed or dry skin
  19. fruit-like breath odor
  20. hives, itching, or skin rash
  21. increased hunger
  22. increased thirst
  23. increased urination
  24. joint or muscle pain
  25. loss of appetite
  26. nausea or vomiting
  27. pinpoint red spots on the skin
  28. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  29. red skin lesions, often with a purple center
  30. red, irritated eyes
  31. seizures
  32. shakiness in the legs, arms, hands, or feet
  33. sore throat
  34. sores, ulcers, or white spots in the mouth or on the lips
  35. sweating
  36. swelling of the feet or lower legs
  37. tightness in the chest
  38. trembling or shaking of the hands or feet
  39. troubled breathing
  40. unexplained weight loss
  41. unusual bleeding or bruising
  42. unusual tiredness or weakness
  43. weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Confusion as to time, place, or person
  2. dark urine
  3. difficult or painful urination
  4. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  5. fever
  6. general feeling of discomfort or illness
  7. hallucinations
  8. headache
  9. holding false beliefs that cannot be changed by fact
  10. increased sweating
  11. irregular, fast or slow, or shallow breathing
  12. light-colored stools
  13. loss of appetite
  14. pale or blue lips, fingernails, or skin
  15. restlessness
  16. sudden decrease in the amount of urine
  17. sweating
  18. trouble sleeping
  19. unpleasant breath odor
  20. unusual excitement, nervousness, or restlessness
  21. vomiting of blood
  22. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Relaxed and calm
  2. sleepiness

Incidence not known

  1. Anxiety
  2. bloated
  3. constipation
  4. continuing ringing or buzzing or other unexplained noise in the ears
  5. depression
  6. earache
  7. excess air or gas in the stomach or intestines
  8. false or unusual sense of well-being
  9. full feeling
  10. hearing loss
  11. heartburn
  12. heavy eyelids
  13. high energy
  14. hot spells
  15. hyperventilation
  16. irritability
  17. numbness
  18. pain in the leg
  19. passing gas
  20. sluggishness
  21. stuffy nose
  22. tingling sensation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



  1. AnswerBot5000

    Not really, Fioricet is a weakend version of percocet, the main side-effect is dependance on the drug, however if you develop a fever that lasts for more than 3 days discontinue and see a doctor.

  2. NurseAnnie

    Reported side effects include drowsiness, dizziness, confusion or lightheadedness, shortness of breath, dry mouth, nausea, vomiting, abdominal pain, or decreased appetite, tiredness, leg pain, or muscle weakness, agitation, irritability, nervousness, anxiety or excitability, rash or itching, feeling of intoxication, headache, and constipation.

  3. Maya

    More common side effects may include:
    Abdominal pain, dizziness, drowsiness, intoxicated feeling, light-headedness, nausea, sedation, shortness of breath, vomiting

    Less common or rare side effects may include:
    Agitation, allergic reactions, constipation, depression, difficulty swallowing, dry mouth, earache, exaggerated feeling of well-being, excessive sweating, excessive urination, excitement, fainting, fatigue, fever, flatulence, headache, heartburn, heavy eyelids, high energy, hot spells, itching, leg pain, mental confusion, muscle fatigue, numbness, rapid heartbeat, ringing in the ears, seizure, shaky feeling, skin redness and/or peeling, sluggishness, stuffy nose, tingling

    Mental and physical dependence can occur with the use of barbiturates such as butalbital when these drugs are taken in higher than recommended doses over long periods of time

  4. Mark C

    According to the FDA, the following side effects have been noted:
    “drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, and intoxicated feeling.”

    Please look at the 13 page report below, which also provides information on the various sub-components and interactions with other drugs.

  5. alibaba sez...

    Side effects

    Side effects for any drug are difficult to predict, but commonly reported side effects for Fioricet include:

    * Abdominal pain
    * Dizziness
    * Drowsiness
    * Intoxicated feeling
    * Light-headedness
    * Nausea
    * Sedation
    * Addiction


    Dangers and risks

    Fioricet contains acetaminophen, which has been shown to cause liver damage at higher dosages. Care should be excercised when using Fioricet to prevent possible liver damage. Fioricet also contains butalbital, which is an addictive, mind (and behavior) altering barbituate. Fioricet can be habit forming. Fioricet should not be mixed with alcohol, both due to the possibility of exacerbating liver damage in combination with the APAP, and due to increased risk of intoxication, respritory depression, and general sedation in combination with the butalbital.

  6. hassen

    * drowsiness;
    * dizziness,, confusion or lightheadedness;
    * shortness of breath;
    * dry mouth;
    * nausea, vomiting, abdominal pain, or decreased appetite;
    * tiredness, leg pain, or muscle weakness;
    * agitation, irritability, nervousness, anxiety or excitability;
    * rash or itching;
    * feeling of intoxication;
    * headache; or
    * constipation.

    If you experience any of the following serious side effects, stop taking acetaminophen/butalbital/caffeine and seek emergency medical attention:

    * an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    * slow, weak breathing;
    * liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue);
    * blood problems (easy or unusual bleeding or bruising); or
    * low blood sugar (fatigue, increased hunger or thirst, dizziness, or fainting).

  7. RKM_LinkinLady

    Common Fioricet Side Effects
    When you take a new medication, common sense tells you that any new occurrences should be noted. With Fioricet, it is no different. Common side effects can include stomach cramping, bloating, feelings of dizziness, sleepiness, feeling light-headed, or even nausea.

  8. kb s

    yes of curse but depends that what kind of pain killers ur they can hur your intestine and kidneys.

  9. cindy k

    Yes i have read that you will get addicted to Fioricet if you take it regularly i suggest you should tell your doctor to RX to something else i take Imitrex for migraines and its very good and you wont get addicted to it.

  10. victim_of_fun00

    Fioricet is butatlbital (a sedative ) along with acetaminophen ( Tylenol ) and caffeine. All medications have side effects- don’t forget that! This one can cause sedation, nausea, vomiting and many other garden-variety side effects. The big thing is that this drug can be habit forming- but under the close care of your doctor, you can use this drug safely. The one thing you need to be carefull of is that this drug contains acetaminophen- which is Tylenol- if you have a fever at some point and take Tylonol make sure you aren’t overdosing yourself. Also, long term daily use of acetaminophen can over time damage your liver. If you cont. to use this drug past 6 mos or so, you should perhaps ask your doctor about stitching to a different drug. Is this taken for Migrain? If so, there are lots of different drugs that can be used. Good luck!

  11. jen2131322

    Like all controlled drugs it has a risk of dependency, if your physician per-scribed it twice daily then it is only to be taken when you are having an actual migraine not if you are just having certain symptoms. You can go to and look up all the side effects and risks.

  12. swissnick

    I would look in a totally different direction to get relief.

    There is a one-time treatment Atlasprofilax that usually makes the migraine disappear – of course there is no guarantee.

    I have experienced the amazing effects myself… 🙂

    Now, the treatment is available in California and Europe only, costing approx. 220 dollars. And it’s worth to travel a far way to make the experience!

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