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The List of Prescription Drugs That May Cause Erectile Dysfunction

Erectile dysfunction (ED) is a common side effect of a number of prescription drugs.

While these medications may treat a disease or condition, in doing so they can affect a man’s hormones, nerves or blood circulation. The result may be ED or an increase in the risk of ED.

If you have ED and think that it may be a result of the medication you are using, do not stop taking the medication. If the problem persists, contact your doctor and he or she may be able to prescribe a different medication. Common medications that may list ED as a potential side effect include:

      • Diuretics (pills that cause an increase in urine flow).
      • Antihypertensives (medication for high blood pressure).
      • Antihistamines.
      • Antidepressants.
      • Parkinson’s disease drugs.
      • Antiarrhythmics (medication for irregular heart action).
      • Tranquilizers.
      • Muscle relaxants.
      • Non-steroidal anti-inflammatory drugs.
      • Histamine H2-receptor antagonists.
      • Hormones.
      • Chemotherapy medications.
      • Prostate cancer drugs.
      • Anti-seizure medications.

Drugs that may cause erection problems

Many medicines and recreational drugs can affect a man’s sexual arousal and sexual performance. What causes erection problems in one man may not affect another man.

Talk to your health care provider if you think that a drug is having a negative effect on your sexual performance. Never stop taking any medicine without first talking to your provider. Some medicines may lead to life-threatening reactions if you do not take care when stopping or changing them.

The following is a list of some medicines and drugs that may cause erectile dysfunction (ED) in men. There may be additional drugs other than those on this list that can cause erection difficulties.

Antidepressants and other psychiatric medicines:

      • Amitriptyline (Elavil)
      • Amoxapine (Asendin)
      • Buspirone (Buspar)
      • Chlordiazepoxide (Librium)
      • Chlorpromazine (Thorazine)
      • Clomipramine (Anafranil)
      • Clorazepate (Tranxene)
      • Desipramine (Norpramin)
      • Diazepam (Valium)
      • Doxepin (Sinequan)
      • Fluoxetine (Prozac)
      • Fluphenazine (Prolixin)
      • Imipramine (Tofranil)
      • Isocarboxazid (Marplan)
      • Lorazepam (Ativan)
      • Meprobamate (Equanil)
      • Mesoridazine (Serentil)
      • Nortriptyline (Pamelor)
      • Oxazepam (Serax)
      • Phenelzine (Nardil)
      • Phenytoin (Dilantin)
      • Sertraline (Zoloft)
      • Thioridazine (Mellaril)
      • Thiothixene (Navane)
      • Tranylcypromine (Parnate)
      • Trifluoperazine (Stelazine)

Antihistamine medicines (certain classes of antihistamines are also used to treat heartburn):

      • Cimetidine (Tagamet)
      • Dimenhydrinate (Dramamine)
      • Diphenhydramine (Benadryl)
      • Hydroxyzine (Vistaril)
      • Meclizine (Antivert)
      • Nizatidine (Axid)
      • Promethazine (Phenergan)
      • Ranitidine (Zantac)

High blood pressure medicines and diuretics (water pills):

      • Atenolol (Tenormin)
      • Bethanidine
      • Bumetanide (Bumex)
      • Captopril (Capoten)
      • Chlorothiazide (Diuril)
      • Chlorthalidone (Hygroton)
      • Clonidine (Catapres)
      • Enalapril (Vasotec)
      • Furosemide (Lasix)
      • Guanabenz (Wytensin)
      • Guanethidine (Ismelin)
      • Guanfacine (Tenex)
      • Haloperidol (Haldol)
      • Hydralazine (Apresoline)
      • Hydrochlorothiazide (Esidrix)
      • Labetalol (Normodyne)
      • Methyldopa (Aldomet)
      • Metoprolol (Lopressor)
      • Nifedipine (Adalat, Procardia)
      • Phenoxybenzamine (Dibenzyline)
      • Phentolamine (Regitine)
      • Prazosin (Minipress)
      • Propranolol (Inderal)
      • Reserpine (Serpasil)
      • Spironolactone (Aldactone)
      • Triamterene (Maxzide)
      • Verapamil (Calan)

Thiazides are the most common cause of erectile dysfunction among the high blood pressure medicines. The next most common cause is beta blockers. Alpha blockers tend to be less likely to cause this problem.

Parkinson disease medicines:

      • Benztropine (Cogentin)
      • Biperiden (Akineton)
      • Bromocriptine (Parlodel)
      • Levodopa (Sinemet)
      • Procyclidine (Kemadrin)
      • Trihexyphenidyl (Artane)

Chemotherapy and hormonal medicines:

      • Antiandrogens (Casodex, Flutamide, Nilutamide)
      • Busulfan (Myleran)
      • Cyclophosphamide (Cytoxan)
      • Ketoconazole
      • LHRH agonists (Lupron, Zoladex)
      • LHRH agonists (Firmagon)

Other medicines:

      • Aminocaproic acid (Amicar)
      • Atropine
      • Clofibrate (Atromid-S)
      • Cyclobenzaprine (Flexeril)
      • Cyproterone
      • Digoxin (Lanoxin)
      • Disopyramide (Norpace)
      • Dutasteride (Avodart)
      • Estrogen
      • Finasteride (Propecia, Proscar)
      • Furazolidone (Furoxone)
      • H2 blockers (Tagamet, Zantac, Pepcid)
      • Indomethacin (Indocin)
      • Lipid-lowering agents
      • Licorice
      • Metoclopramide (Reglan)
      • NSAIDs (ibuprofen, etc.)
      • Orphenadrine (Norflex)
      • Prochlorperazine (Compazine)
      • Pseudoephedrine (Sudafed)
      • Sumatriptan (Imitrex)

Opiate analgesics (painkillers):

      • Codeine
      • Fentanyl (Innovar)
      • Hydromorphone (Dilaudid)
      • Meperidine (Demerol)
      • Methadone
      • Morphine
      • Oxycodone (Oxycontin, Percodan)

Recreational drugs:

      • Alcohol
      • Amphetamines
      • Barbiturates
      • Cocaine
      • Marijuana
      • Heroin
      • Nicotine

Alternative Names

Impotence caused by medications; Drug-induced erectile dysfunction; Prescription medicines and impotence